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CpG deficiency, dinucleotide distributions and nucleosome positioning

Adams, Roger L. P., Davis, Terence, Rinaldi, Angela and Eason, Robert 1987. CpG deficiency, dinucleotide distributions and nucleosome positioning. European Journal of Biochemistry 165 (1) , pp. 107-115. 10.1111/j.1432-1033.1987.tb11200.x

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The dinucleotide CpG is deficient in (A + T)-rich regions of vertebrate DNA in both coding and non-coding sequences and there is a corresponding increase above expectation in the occurrence of TpG and CpA. By contrast in (G + C)-rich regions no deficiency of CpG is found. Such (G + C)-rich sequences, containing the expected number of CpG dinucleotides, alternate along the genome with (A + T)-rich sequences which have a lower than expected CpG content. The G + C content of vertebrate DNA can oscillate with a period of 150–200 bp and this may be a factor in positioning nucleosomes. The role of mutagenesis in loss of CpG and increase of A + T, particularly in non-coding regions, is discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Publisher: Wiley
ISSN: 0014-2956
Last Modified: 04 Jun 2017 06:40

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