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Dysthyroid optic neuropathy: a clinical diagnosis or a definable entity?

Dayan, Colin Mark ORCID: and Dayan, Margaret R. 2007. Dysthyroid optic neuropathy: a clinical diagnosis or a definable entity? British Journal of Ophthalmology 91 (4) , pp. 409-410. 10.1136/bjo.2006.110932

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The diagnosis of DON should be made correctly; those affected should be treated promptly and those unaffected spared the risks associated with treatment. Optic neuropathy is the most feared complication of thyroid eye disease (TED). Thankfully, it is rare, affecting perhaps 4–8% of patients with TED,1,2 but when diagnosed requires urgent treatment with medical (eg, high-dose intravenous steroids) or surgical decompression to avoid permanent or progressive visual loss.3 However, both these treatments carry a considerable risk of morbidity. Hence, it is essential that the diagnosis is made correctly in order that those affected are treated promptly and those unaffected are spared the risks associated with treatment. Several features are used to make the diagnosis of dysthyroid optic neuropathy (DON) (table 1).1,2,4 The assumption is generally made that if any of these features are present in an individual with dysthyroid eye disease and no other explanation of the defect is apparent, then the individual has DON. Unfortunately, alternative causes for visual impairment are often present in TED—estimated at 20% or more of cases.5,6 Several of these may be linked to the TED itself (eg, keratopathy or glaucoma due to increased orbital venous pressure),7 whereas others are coincidental (eg, amblyopia, uncorrected refractive errors or cataracts). This poses a considerable problem: if the alternative causes are not identified, then DON may be inappropriately diagnosed, whereas if alternative causes are present, visual impairment might be inappropriately ascribed to them when in fact DON is present.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: BMJ Publishing Group
ISSN: 0007-1161
Last Modified: 27 Oct 2022 08:54

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