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Mild androgen insensitivity presenting with sexual dysfunction

Cundy, T. F., Rees, M., Evans, Bronwen Alice James ORCID:, Hughes, I. A., Butler, J. and Wheeler, M. J. 1986. Mild androgen insensitivity presenting with sexual dysfunction. Fertility and Sterility 46 (4) , pp. 721-723.

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A man presented with sexual dysfunction and was found to have elevated serum levels of both gonadotropins and T, suggesting AIS. Small external genitalia were the only phenotypic abnormality. Serum T levels increased appropriately in response to hCG and CC, but the patient was severely oligospermic, and testicular biopsy study revealed profoundly impaired spermatogenesis. Studied on androgen receptors in genital skin fibroblasts were normal. PAIS with a virtually normal male phenotype can present in adulthood with sexual dysfunction as well as infertility. As with the syndrome of complete AIS, androgen receptor studies indicate that this is a heterogeneous group of disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0015-0282
Last Modified: 27 Oct 2022 09:26

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