Physiological significance of L-amino acid sensing by extracellular Ca2+-sensing receptors

Mun, H. -C., Conigrave, A. D. and Brennan, Sarah C. ORCID: https://orcid.org/0000-0002-8719-4367 2007. Physiological significance of L-amino acid sensing by extracellular Ca2+-sensing receptors. Biochemical Society Transactions 35 (5) , pp. 1195-1198. 10.1042/BST0351195

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Abstract

The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca2+o (extracellular Ca2+) sensing, the CaR (Ca2+-sensing receptor) also responds to L-amino acids. L-amino acids appear to activate, predominantly, a signalling pathway coupled with intracellular Ca2+ mobilization, require a threshold concentration of Ca2+o for efficacy and sensitize the receptor to activation by Ca2+o. Here, we review the evidence that the CaR, like other closely related members of the class 3 GPCR (G-protein-coupled receptor) family including GPRC6A, is a broad-spectrum amino acid-sensing receptor, consider the nature of the signalling response to amino acids and discuss its physiological significance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Portland Press
ISSN:	0300-5127
Last Modified:	27 Oct 2022 09:26
URI:	https://orca.cardiff.ac.uk/id/eprint/65844

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