The complete amino acid sequence of two types of subtilisin, BPN' and Carlsberg

Smith, E. L., Markland, F. S., Kasper, C. B., DeLange, R. J., Landon, M. and Evans, William Howard 1966. The complete amino acid sequence of two types of subtilisin, BPN' and Carlsberg. Journal of Biological Chemistry 241 (24) , pp. 5974-5976.

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Abstract

The complete amino acid sequences of subtilisins BPN' (Nagarse) and Carlsberg have been determined. Subtilisin BPN' consists of a single peptide chain of 275 amino acid residues, whereas the Carlsberg enzyme contains 274 residues and differs in a total of 83 residues. The enzymes are distinct from "serine proteinases" of animal origin. Amino acid replacements permit preliminary identification of areas critical for structure-function relationships and some assessment of possible genetic mechanisms which have led to differences in sequence.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	American Society for Biochemistry and Molecular Biology
ISSN:	0021-9258
Last Modified:	17 Mar 2021 02:53
URI:	https://orca.cardiff.ac.uk/id/eprint/66370

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