Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation

Murdoch, H., Milligan, G., Kellett, E., White, J. H. and Feng, Gui Jie 2004. Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation. Biochemical Society Transactions 32 (5) , pp. 878-880. 10.1042/BST0320878

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Abstract

A substantial number of G-protein-coupled receptor-interacting proteins have been identified initially by the use of yeast two-hybrid screens. Using the C-terminal tail of both opioid receptors and the melanin concentrating hormone receptor-1 as bait, the actin and intermediate filament-binding protein periplakin was isolated. In each case, the site of interaction is within helix VIII of the receptor and periplakin limits agonist-mediated G-protein activation potentially by competing with G-protein for this region of the receptor.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	Portland Press
ISSN:	0300-5127
Last Modified:	17 Jan 2019 09:41
URI:	https://orca.cardiff.ac.uk/id/eprint/66417

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