Thoughts on Aneuploidy

Torres, Eduardo Miguel, Williams, B. R., Tang, Y.- C. and Amon, A. 2011. Thoughts on Aneuploidy. Cold Spring Harbor Symposia on Quantitative Biology 75 , pp. 445-451. 10.1101/sqb.2010.75.025

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Abstract

Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level. Furthermore, we find that aneuploid cells exhibit phenotypes consistent with increased energy need and proteotoxic stress. These observations, together with the finding that the additional chromosomes found in aneuploid cells are active, lead us to propose that aneuploidy causes an increased burden on protein synthesis and protein quality-control pathways and so induces an aneuploidy stress response.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Cold Spring Harbor Laboratory
ISSN:	0091-7451
Last Modified:	23 Mar 2017 05:07
URI:	https://orca.cardiff.ac.uk/id/eprint/66763

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