Aneuploidy: cells losing their balance

Torres, Eduardo Miguel, Williams, B. R. and Amon, A. 2008. Aneuploidy: cells losing their balance. Genetics 179 (2) , pp. 737-746. 10.1534/genetics.108.090878

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Abstract

A change in chromosome number that is not the exact multiple of the haploid karyotype is known as aneuploidy. This condition interferes with growth and development of an organism and is a common characteristic of solid tumors. Here, we review the history of studies on aneuploidy and summarize some of its major characteristics. We will then discuss the molecular basis for the defects caused by aneuploidy and end with speculations as to whether and how aneuploidy, despite its deleterious effects on organismal and cellular fitness, contributes to tumorigenesis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Genetics Society of America
ISSN:	0016-6731
Last Modified:	23 Mar 2017 05:07
URI:	https://orca.cardiff.ac.uk/id/eprint/66766

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