Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

Carriba, Paulina, Ortiz, Oskar, Patkar, Kshitij, Justinova, Zuzana, Stroik, Jessica, Themann, Andrea, Müller, Christa, Woods, Anima S., Hope, Bruce T., Ciruela, Francisco, Casadó, Vicent, Canela, Enric I., Lluis, Carme, Goldberg, Steven R., Moratalla, Rosario, Franco, Rafael and Ferré, Sergi 2007. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 32 (11) , pp. 2249-2259. 10.1038/sj.npp.1301375

Full text not available from this repository.

Abstract

The mechanism of action responsible for the motor depressant effects of cannabinoids, which operate through centrally expressed cannabinoid CB1 receptors, is still a matter of debate. In the present study, we report that CB1 and adenosine A2A receptors form heteromeric complexes in co-transfected HEK-293T cells and rat striatum, where they colocalize in fibrilar structures. In a human neuroblastoma cell line, CB1 receptor signaling was found to be completely dependent on A2A receptor activation. Accordingly, blockade of A2A receptors counteracted the motor depressant effects produced by the intrastriatal administration of a cannabinoid CB1 receptor agonist. These biochemical and behavioral findings demonstrate that the profound motor effects of cannabinoids depend on physical and functional interactions between striatal A2A and CB1 receptors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Nature Publishing Group
ISSN: 0893-133X
Last Modified: 17 Mar 2021 02:42
URI: https://orca.cardiff.ac.uk/id/eprint/66912

Citation Data

Cited 197 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item