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The thalamocortical network as a single slow wave-generating unit

Crunelli, Vincenzo ORCID:, David, Francois, Lorincz, Magor L. and Hughes, Stuart W. 2015. The thalamocortical network as a single slow wave-generating unit. Current Opinion in Neurobiology 31 , pp. 72-80. 10.1016/j.conb.2014.09.001

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During non-REM sleep the EEG is dominated by slow waves which result from synchronized UP and DOWN states in the component neurons of the thalamocortical network. This review focuses on four areas of recent progress in our understanding of these events. Thus, it has now been conclusively demonstrated that the full expression of slow waves, both of natural sleep and anesthesia, requires an essential contribution by the thalamus. Furthermore, the modulatory role of brainstem transmitters, the function of cortical inhibition and the relative contribution of single neocortical neurons to EEG slow waves have started to be carefully investigated. Together, these new data confirm the view that a full understanding of slow waves can only be achieved by considering the thalamocortical network as a single functional and dynamic unit for the generation of this key EEG rhythm.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier
ISSN: 0959-4388
Date of First Compliant Deposit: 30 March 2016
Last Modified: 07 Nov 2023 04:02

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