P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma

Shnyder, S. D., Hayes, Anthony, Pringle, J. and Archer, Charles 1998. P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. British Journal of Cancer 78 , pp. 757-759. 10.1038/bjc.1998.573

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Abstract

The expression of the drug resistance (DR) mediators P-glycoprotein (P-gp) and the metallothioneins (MT) was assessed immunohistochemically in biopsy material from patients with high-grade malignant osteosarcoma (OS). No significant difference was found in survival rate between expressors of both P-gp and MT and non-expressors. Thus, it was concluded that lack of expression of these two drug resistance-related proteins does not appear to confer any advantage in terms of patient survival in osteosarcoma.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Nature Publishing Group
ISSN:	0007-0920
Last Modified:	04 Jun 2017 07:45
URI:	https://orca.cardiff.ac.uk/id/eprint/67548

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