Study into molecular targets of a neuroprotective compound dimebon using a transgenic mice line

Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Ustiugov, A. A., Kokhan, V. S., Tarasova, T. V., Medvedeva, V. K., Khritankova, I. V., Bahcurin, S. O. and Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 2014. Study into molecular targets of a neuroprotective compound dimebon using a transgenic mice line. Biomeditsinskaia khimiia 60 (3) , pp. 354-363.

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Abstract

In the present study we have used a transgenic mice overexpressing an amyloidogenic protein, gamma-synuclein, in the nervous system to address the effect of dimebon on proteinopathy progression. Neuroprotective effect of chronic dimebon administration in these mice at organismal level was confirmed by the increased lifespan. Using histological and biochemical approaches we have demonstrated that dimebon reduced the number of amyloid inclusions in spinal cord of transgenic animals and decreased the content of ubiquitinated proteins in detergent-insoluble fractions. These effects are likely to occur at the level of aggregated protein species, since transgene expression was not altered. Thus, pathological protein aggregation serves as one of dimebon targets in neurodegeneration.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	Dimebon; neurodegeneration; neuroprotection; protein aggregation; transgenic models.
Publisher:	Rossiiskaya Akademiya
ISSN:	2310-6972
Last Modified:	27 Oct 2022 10:02
URI:	https://orca.cardiff.ac.uk/id/eprint/68644

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