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Response of refractory ITP in a patient with common variable immunodeficiency (CVID) to treatment with rituximab

El-Shanawany, Tariq, Williams, Paul Eirian and Jolles, Stephen 2007. Response of refractory ITP in a patient with common variable immunodeficiency (CVID) to treatment with rituximab. Journal of Clinical Pathology 60 (6) , pp. 715-716. 10.1136/jcp.2006.041426

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CVID is the commonest serious antibody deficiency in adults. There are a number of associated complications including autoimmunity, of which immune thrombocytopenic purpura (ITP) is a relatively common example. ITP usually responds to treatment with corticosteroids, other immunosuppression, splenectomy or high dose intravenous immunologlobulin (IVIG). The management of ITP refractory to these treatments remains challenging. We report a patient with CVID who developed ITP and remained platelet transfusion dependent despite high dose IVIG and splenectomy. Treatment with rituximab resulted in normalisation of the platelet count and the patient remains transfusion independent at one year following rituximab therapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Uncontrolled Keywords: idiopathic thrombocytopenic purpura; common variable immunodeficiency; rituximab
Publisher: BMJ Journals
ISSN: 1472-4146
Date of First Compliant Deposit: 30 March 2016
Last Modified: 11 Jun 2023 18:02

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