Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Does vitamin D mediate the protective effects of time outdoors on myopia? Findings from a prospective birth cohort

Guggenheim, Jeremy Andrew ORCID:, Williams, Cathy, Northstone, Kate, Howe, Laura D., Tilling, Kate, St Pourcain, Beate, McMahon, George and Lawlor, Debbie A. 2014. Does vitamin D mediate the protective effects of time outdoors on myopia? Findings from a prospective birth cohort. Investigative Ophthalmology and Visual Science 55 (12) , pp. 8550-8558. 10.1167/iovs.14-15839

Full text not available from this repository.


Purpose. More time outdoors is associated with a lesser risk of myopia, but the underlying mechanism is unclear. We tested the hypothesis that 25-hydroxyvitamin D (vitamin D) mediates the protective effects of time outdoors against myopia. Methods. We analyzed data for children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) population-based birth cohort: noncycloplegic autorefraction at age 7 to 15 years; maternal report of time outdoors at age 8 years and serum vitamin D2 and D3 at age 10 years. A survival analysis hazard ratio (HR) for incident myopia was calculated for children spending a high- versus low-time outdoors, before and after controlling for vitamin D level (N = 3677). Results. Total vitamin D and D3, but not D2, levels were higher in children who spent more time outdoors (mean [95% confidence interval (CI)] vitamin D in nmol/L: Total, 60.0 [59.4–60.6] vs. 56.9 [55.0–58.8], P = 0.001; D3, 55.4 [54.9–56.0] vs. 53.0 [51.3–54.9], P = 0.014; D2, 5.7 [5.5–5.8] vs. 5.4 [5.1–5.8], P = 0.23). In models including both time outdoors and sunlight-exposure–related vitamin D, there was no independent association between vitamin D and incident myopia (Total, HR = 0.83 [0.66–1.04], P = 0.11; D3, HR = 0.89 [0.72–1.10], P = 0.30), while time outdoors retained the same strong negative association with incident myopia as in unadjusted models (HR = 0.69 [0.55–0.86], P = 0.001). Conclusions. Total vitamin D and D3 were biomarkers for time spent outdoors, however there was no evidence they were independently associated with future myopia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: Association for Research in Vision and Ophthalmology
ISSN: 0146-0404
Date of Acceptance: 28 October 2014
Last Modified: 28 Oct 2022 08:26

Citation Data

Cited 63 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item