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Body stature growth trajectories during childhood and the development of myopia

Northstone, Kate, Guggenheim, Jeremy Andrew ORCID:, Howe, Laura D., Tilling, Kate, Paternoster, Lavinia, Kemp, John P., McMahon, George and Williams, Cathy 2013. Body stature growth trajectories during childhood and the development of myopia. Ophthalmology 120 (5) , pp. 1064-1073. 10.1016/j.ophtha.2012.11.004

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Purpose Stature at a particular age can be considered the cumulative result of growth during a number of preceding growth trajectory periods. We investigated whether height and weight growth trajectories from birth to age 10 years were related to refractive error at ages 11 and 15 years, and eye size at age 15 years. Design Prospective analysis in a birth cohort. Participants Children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) U.K. birth cohort (minimum N = 2676). Methods Growth trajectories between birth and 10 years were modeled from a series of height and weight measurements (N = 6815). Refractive error was assessed by noncycloplegic autorefraction at ages 11 and 15 years (minimum N = 4737). Axial length (AXL) and radius of corneal curvature were measured with an IOLMaster (Carl Zeiss Meditec, Welwyn Garden City, U.K.) at age 15 years (minimum N = 2676). Growth trajectories and an allelic score for 180 genetic variants associated with adult height were tested for association with refractive error and eye size.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: Elsevier
Last Modified: 28 Oct 2022 08:27

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