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A comparison of 8% and 12% sevoflurane for inhalation induction in adults

Goodwin, Naomi, Campbell, A. E., Hall, Judith Elizabeth ORCID:, Plummer, S. and Harmer, M. 2004. A comparison of 8% and 12% sevoflurane for inhalation induction in adults. Anaesthesia -London- 59 (1) , pp. 15-19. 10.1111/j.1365-2044.2004.03481.x

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Sevoflurane is a non-pungent volatile anaesthetic agent with a low blood-gas solubility coefficient. It has been studied in concentrations of up to 8% for induction of anaesthesia. Previous work has suggested that there may be a ceiling effect with increasing concentration of sevoflurane above 6%, but there are no published studies using 12% sevoflurane. This study compared 8 and 12% sevoflurane to induce anaesthesia in adults. Sevoflurane was administered using two adapted datum vaporisers with the interlock removed. Induction with 12% sevoflurane compared to 8% sevoflurane produced a significant decrease in the time to achieve central pupils, corresponding to surgical anaesthesia and the third part of Guedel's stage 3 of anaesthesia (mean time (SD) 201 s (81) and 247 s (39), respectively, p < 0.05). Twelve-percent sevoflurane produced a similar stable cardiovascular profile to 8% sevoflurane, and there was no increase in respiratory complications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 0003-2409
Last Modified: 28 Oct 2022 08:36

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