Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia

Jeffs, S. A., Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 and Morris, S. 2002. Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia. British Journal of Anaesthesia 89 (3) , pp. 424-427. 10.1093/bja/aef216

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Abstract

BACKGROUND: Clonidine is an alpha 2 adrenergic agonist with analgesic properties. This study aimed to see if the addition of clonidine to morphine when given by patient-controlled analgesia (PCA) would improve analgesia beyond the first 12 h after surgery. METHODS: Sixty patients undergoing lower abdominal surgery were recruited into a randomized double blind study. At the end of surgery Group C received an infusion of clonidine 4 micrograms kg-1 over 20 min, PCA clonidine 20 micrograms and morphine 1 mg bolus. Group M received an infusion of saline and then PCA morphine 1 mg bolus. Pain, sedation and nausea and vomiting were assessed after 12, 24 and 36 h, and satisfaction with analgesia was assessed at 36 h. RESULTS: Pain scores were significantly lower in Group C between 0 and 12 h, but thereafter there was no difference. Morphine consumption was the same for both groups until 24-36 h. Nausea and vomiting was significantly reduced in Group C between 0 and 24 h. Patients in Group C were significantly happier with their pain relief (four-point scale).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Oxford University Press
ISSN:	0007-0912
Last Modified:	28 Oct 2022 08:37
URI:	https://orca.cardiff.ac.uk/id/eprint/71454

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