Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents

Zatman, T. F., Hall, Judith Elizabeth ORCID: https://orcid.org/0000-0002-6770-7372 and Harmer, M. 2001. Gastric residual volume in children: a study comparing efficiency of erythromycin and metoclopramide as prokinetic agents. British Journal of Anaesthesia 86 (6) , pp. 869-871. 10.1093/bja/86.6.869

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Abstract

Metoclopramide may be used to stimulate gastric emptying when anaesthetizing children for emergency operations. Unfortunately, metoclopramide is associated with extrapyramidal side effects. Erythromycin, a motilin receptor agonist, is a prokinetic agent but its use has been little investigated in children. This randomized double-blind study compared the effects of premedication with oral metoclopramide 0.15 mg kg(-1) or erythromycin 1 mg kg(-1) on gastric emptying in 80 children undergoing tonsillectomy. Pre-operative fluids, premedication and anaesthetic technique were standardized and gastric volume was measured with an orogastric tube. Post-operative nausea and vomiting was recorded. Metoclopramide and erythromycin produced similar gastric volumes (0.29 and 0.24 ml kg(-1)) and there was no difference in post-operative vomiting. In the erythromycin group there were more patients with negative aspirates (45.9%) than in the metoclopramide group (35.1%), but the difference was not statistically significant. These results indicate that erythromycin may be as effective as metoclopramide as a prokinetic agent.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Publisher:	Oxford University Press
ISSN:	0007-0912
Last Modified:	28 Oct 2022 08:37
URI:	https://orca.cardiff.ac.uk/id/eprint/71455

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