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Co-ordination of Ca2+ signalling in mammalian cells by the new Ca2+-releasing messenger NAADP

Cancela, Jose M., Charpentier, Gilles and Petersen, Ole Holger 2003. Co-ordination of Ca2+ signalling in mammalian cells by the new Ca2+-releasing messenger NAADP. Pflugers Archiv: European Journal of Physiology 446 (3) , pp. 322-327. 10.1007/s00424-003-1035-x

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Ca2+ signalling is one of the most important means in mammalian cells of relaying the action of hormones and neurotransmitters. The great diversity of agonist-induced Ca2+ signatures, visualized by optical imaging techniques, can be explained by the production of intracellular messengers triggering Ca2+ release from internal stores and/or by different coupling of Ca2+ release to Ca2+ entry. Several messengers, such as inositol trisphosphate and cyclic ADP-ribose, have been identified to date. More recent studies have reported the important role of a newly discovered Ca2+ releasing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). These studies have shown important interactions of these messengers in the generation of specific Ca2+ signals. NAADP acts at a very low concentration and seems to have a key role in sensitising cyclic ADP-ribose and inositol trisphosphate receptors. These points will be discussed in the present review.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: Springer
ISSN: 0031-6768
Last Modified: 04 Jun 2017 08:01

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