Comparison of the repeatability of GABA-edited magnetic resonance spectroscopy with and without macromolecule suppression

Mikkelsen, Mark ORCID: https://orcid.org/0000-0002-0349-3782, Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475, Sumner, Petroc ORCID: https://orcid.org/0000-0002-0536-0510 and Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245 2016. Comparison of the repeatability of GABA-edited magnetic resonance spectroscopy with and without macromolecule suppression. Magnetic Resonance in Medicine 75 (3) , pp. 946-953. 10.1002/mrm.25699

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Abstract

Purpose The inhibitory neurotransmitter γ-aminobutyric acid (GABA) can be measured in vivo using edited magnetic resonance spectroscopy (MRS), but quantification suffers from contamination by macromolecules (MM). It is possible to suppress this contamination using symmetric editing, but this procedure potentially compromises reliability of the GABA measurement. The aim of this study was to compare the repeatability of GABA-edited MRS with and without MM suppression. Methods GABA′ (non-MM contaminated) and GABA′+MM (MM-contaminated) concentration was measured in the occipital lobe (OCC) and anterior cingulate (AC) using symmetric and standard editing (n = 15). Each method was performed twice in each region. Results Within-participant coefficients of variation for each technique were 4.0% (GABA′+MM) and 8.6% (GABA′) in the OCC and 14.8% (GABA′+MM) and 12.6% (GABA′) in the AC. Intraclass correlation coefficients were better for the suppression method than standard editing in both the OCC (0.72 versus 0.67) and AC (0.41 versus 0.16). These findings were replicated in the OCC of a second cohort (n = 15). Conclusion Symmetric suppression is shown to be comparable in repeatability to standard GABA-editing. Measuring a purer quantification of GABA becomes increasingly important as more research is conducted on links between GABA concentration, pathology and healthy behavior.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	GABA; macromolecules; MRS; repeatability; symmetric suppression
Additional Information:	Article first published online: 29 APR 2015
Publisher:	John Wiley & Sons
ISSN:	0740-3194
Date of Acceptance:	24 February 2015
Last Modified:	28 Oct 2022 09:01
URI:	https://orca.cardiff.ac.uk/id/eprint/72968

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