Oxygen-radical production during inflammation may be limited by oxygen concentration

Edwards, S. W., Hallett, Maurice Bartett ORCID: https://orcid.org/0000-0001-8197-834X and Campbell, A. K. 1984. Oxygen-radical production during inflammation may be limited by oxygen concentration. Biochemical Journal 217 (3) , pp. 851-854.

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Abstract

The relationship between oxygen-radical production by rat polymorphonuclear leucocytes and O2 concentration was established by the measurement of luminol-dependent chemiluminescence at defined O2 concentrations. The O2 concentration that gave 50% of the maximum stimulated oxygen-radical production was 31 +/- 9 microM for non-opsonized latex beads and 22 +/- 9 microM for chemotactic peptide. The O2 concentration in rheumatoid synovial fluid was approx. 30 microM. It is therefore proposed that radical production at an inflammatory site may be limited by O2 concentration

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Animals, Chemotactic Factors/pharmacology, Cytochalasin B/pharmacology, Free Radicals, In Vitro Techniques, Inflammation/metabolism*, Latex/pharmacology, Luminescent Measurements, Neutrophils/drug effects, Neutrophils/metabolism*, Oxygen/metabolism*, Rats
Publisher:	Biochemical Society
ISSN:	0264-6021
Last Modified:	28 Oct 2022 09:04
URI:	https://orca.cardiff.ac.uk/id/eprint/73165

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