Morgan, Kelly ![]() |
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Abstract
BACKGROUND:This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. METHODS:A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. FINDINGS:We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)). CONCLUSION:The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer) Social Sciences (Includes Criminology and Education) |
Additional Information: | Pdf uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/1932-6203/ (accessed 22.5.15). |
Publisher: | Public Library of Science |
ISSN: | 1932-6203 |
Date of First Compliant Deposit: | 30 March 2016 |
Last Modified: | 28 Oct 2022 09:08 |
URI: | https://orca.cardiff.ac.uk/id/eprint/73452 |
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