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Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex

Shaw, Alexander D. ORCID:, Saxena, Neeraj ORCID:, Jackson, Laura E., Hall, Judith E. ORCID:, Singh, Krish D. ORCID: and Muthukumaraswamy, Suresh D. ORCID: 2015. Ketamine amplifies induced gamma frequency oscillations in the human cerebral cortex. European Neuropsychopharmacology 25 (8) , pp. 1136-1146. 10.1016/j.euroneuro.2015.04.012

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At subanaesthetic doses, ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant efficacy in patients with treatment-resistant depression. The mechanism of action of ketamine is complex and not fully understood, with altered glutamatergic function and alterations of high-frequency oscillatory power (Wood et al., 2012) noted in animal studies. Here we used magnetoencephalography (MEG) in a single blind, crossover study to assess the neuronal effects of 0.5 mg/kg intravenous ketamine on task-related high-frequency oscillatory activity in visual and motor cortices. Consistent with animal findings, ketamine increased beta amplitudes, decreased peak gamma frequency in visual cortex and significantly amplified gamma-band amplitudes in motor and visual cortices. The amplification of gamma-band activity has previously been linked in animal studies to cortical pyramidal cell disinhibition. This study provides direct translatable evidence of this hypothesis in humans, which may underlie the anti-depressant actions of ketamine.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Ketamine; Gamma oscillations; NMDA receptor; Magnetoencephalography; Visual cortex; Motor cortex
Publisher: Elsevier
ISSN: 0924-977X
Date of Acceptance: 10 April 2015
Last Modified: 23 May 2024 01:13

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