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Design and application of a low-temperature continuous flow chemistry platform

Newby, James A., Blaylock, D. Wayne, Witt, Paul M., Pastre, Julio C., Zacharova, Marija K., Ley, Steven V. and Browne, Duncan L. 2014. Design and application of a low-temperature continuous flow chemistry platform. Organic Process Research and Development 18 (10) , pp. 1211-1220. 10.1021/op500213j

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Abstract

A flow reactor platform technology applicable to a broad range of low temperature chemistry is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume. The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
ISSN: 1083-6160
Last Modified: 06 Jan 2021 02:36
URI: https://orca.cardiff.ac.uk/id/eprint/73845

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