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Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia

Pocklington, Andrew ORCID:, Rees, Elliott ORCID:, Walters, James T. R. ORCID:, Han, Jun, Kavanagh, David H., Chambert, Kimberly D., Holmans, Peter ORCID:, Moran, Jennifer L., McCarroll, Steven A., Kirov, George ORCID:, O'Donovan, Michael C. ORCID: and Owen, Michael J. ORCID: 2015. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86 (5) , pp. 1203-1214. 10.1016/j.neuron.2015.04.022

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We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between the disorder and chromosomal copy number (CNV) burden. We combined data from 5,745 cases and 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 cases and 16,416 controls, we show for the first time that case CNVs are enriched for genes involved in GABAergic neurotransmission. Consistent with non-genetic reports of GABAergic deficits in schizophrenia, our findings now show disrupted GABAergic signaling is of direct causal relevance, rather than a secondary effect or due to confounding. Additionally, we independently replicate and greatly extend previous findings of CNV enrichment among genes involved in glutamatergic signaling. Given the strong functional links between the major inhibitory GABAergic and excitatory glutamatergic systems, our findings converge on a broad, coherent set of pathogenic processes, providing firm foundations for studies aimed at dissecting disease mechanisms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Advanced Research Computing @ Cardiff (ARCCA)
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: This is an open access article under the CC BY license
Publisher: Elsevier (Cell Press)
ISSN: 0896-6273
Funders: MRC
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 16 April 2015
Last Modified: 15 Mar 2024 07:22

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