Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain

Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Andrei, G., Snoeck, R., De Clercq, E. and Balzarini, J. 2000. Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain. Bioorganic & Medicinal Chemistry Letters 10 (11) , pp. 1215-1217. 10.1016/S0960-894X(00)00193-1

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Abstract

Preliminary SAR studies on the side chain of a new class of antiviral nucleosides have shown that terminal substitution in the side-chain, with a halogen atom, lead to potent and highly speci®c anti-VZV agents.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RS Pharmacy and materia medica
ISSN:	0960894X
Last Modified:	17 Oct 2022 10:15
URI:	https://orca.cardiff.ac.uk/id/eprint/7490

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