Genetics of bipolar disorder

Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 and Sklar, P. 2013. Genetics of bipolar disorder. The Lancet 381 (9878) , pp. 1654-1662. 10.1016/S0140-6736(13)60855-7

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Abstract

Studies of families and twins show the importance of genetic factors affecting susceptibility to bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN. Strong evidence exists for a polygenic contribution to risk (ie, many risk alleles of small effect). A notable finding is the overlap of susceptibility between bipolar disorder and schizophrenia for several individual risk alleles and for the polygenic risk. By contrast, genomic structural variation seems to play a smaller part in bipolar disorder than it does in schizophrenia. Together, these genetic findings suggest directions for future studies to delineate the aetiology and pathogenesis of bipolar disorder, indicate the need to re-evaluate our diagnostic classifications, and might eventually pave the way for major improvements in clinical management.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Bipolar Disorder; Genetic Predisposition to Disease; Genetic Testing; Genome-Wide Association Study; Genotype; Humans; Molecular Biology; Phenotype; Polymorphism, Single Nucleotide; Risk; Risk Assessment
Publisher:	Elsevier
ISSN:	0140-6736
Last Modified:	28 Oct 2022 09:42
URI:	https://orca.cardiff.ac.uk/id/eprint/75409

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