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Genetic interactions between the Wilms’ Tumor 1 Gene and the p53 Gene

Menke, Aswin, Clarke, Alan Richard ORCID:, Leitch, Andrea, Ijpenberg, Annemieke, Williamson, Kathy, Spraggon, Lee, Harrison, David James and Hastie, Nicholas 2002. Genetic interactions between the Wilms’ Tumor 1 Gene and the p53 Gene. Cancer Research 62 (22) , pp. 6615-6620.

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In recent years, a number of proteins have been identified that can modify the activities of the Wilms’ Tumor 1 (WT1) proteins. One of these modifiers is the p53 protein. To investigate a genetic interaction between the p53 gene and the wt1 gene, we have crossed their respective knockout mice. The absence of p53 appears to have no gross effect on the phenotype of wt1-null mice. Both wt1-null and double-null embryos develop pericardial bleeding and die in utero. In adult p53-null mice, wt1-heterozygosity (wt1het) predisposes to an earlier onset of lymphomagenesis and the development of kidney abnormalities resembling oncocytoma in humans. wt1-heterozygosity alone predisposes to the development of glomerular sclerosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: American Association for Cancer Research
ISSN: 0008-5472
Funders: Wellcome Trust, National Kidney Research Fund
Date of Acceptance: 20 September 2002
Last Modified: 28 Oct 2022 09:43

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