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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk

Chubb, D., Weinhold, N., Broderick, P., Chen, B., Johnson, D., Försti, A., Vijayakrishnan, J., Migliorini, G., Dobbins, S., Holroyd, A., Hose, D., Walker, B., Davies, F., Gregory, W., Jackson, G., Irving, J., Pratt, G., Fegan, Christopher Daniel, Fenton, J., Neben, K., Hoffmann, P., Nöthen, M., Mühleisen, T., Eisele, L., Ross, F., Straka, C., Einsele, H., Langer, C., Dörner, E., Allan, J., Jauch, A., Morgan, G., Hemminki, K., Houlston, R. and Goldschmidt, H. 2013. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nature Genetics 45 (10) , pp. 1221-1225. 10.1038/ng.2733

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To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10 -14), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10 -11), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10 -9) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10 -16). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: Case-Control Studies; Chromosome Aberrations; Chromosomes, Human; Genetic Predisposition to Disease; Humans; Multiple Myeloma
Publisher: Nature Publishing Group
ISSN: 1061-4036
Last Modified: 04 Jun 2017 08:18

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