Roberts, G. M., Davies, E. V. and Hallett, Maurice Bartlett ![]() |
Abstract
In the work reported here evidence is provided that shows the slow wave of Ca2+ large neonatal myeloid cells provoked by formyl-Met-Leu-Phe was generated by spatially delayed Ca2+ influx. Evidence is provided that the delay in Ca2+ influx was the result of diffusion of a factor from the Ca2+ storage site, which is responsible for Ca2+ channel opening. The location of the Ca2+ release site was correlated with a region near the nucleus, probably a specialized region of endoplasmic reticulum. It is proposed that similar mechanisms of Ca2+ signaling occur in mature myeloid cells, such as neutrophils, but on a shorter time scale as a consequence of their smaller size.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Uncontrolled Keywords: | Calcium/metabolism*, Calcium Channels/physiology, Cells, Cultured, Cytosol/metabolism, Diffusion, Humans |
Publisher: | Bethesda, MD : Society for Leukocyte Biology |
ISSN: | 0741-5400 |
Last Modified: | 28 Oct 2022 09:51 |
URI: | https://orca.cardiff.ac.uk/id/eprint/75894 |
Citation Data
Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
![]() |
Edit Item |