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Slow Ca2+ waves in large myeloid cells as a result of a diffusible cytosolic factor

Roberts, G. M., Davies, E. V. and Hallett, Maurice Bartlett ORCID: 1995. Slow Ca2+ waves in large myeloid cells as a result of a diffusible cytosolic factor. Journal of leukocyte biology 57 (6) , pp. 837-841.

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In the work reported here evidence is provided that shows the slow wave of Ca2+ large neonatal myeloid cells provoked by formyl-Met-Leu-Phe was generated by spatially delayed Ca2+ influx. Evidence is provided that the delay in Ca2+ influx was the result of diffusion of a factor from the Ca2+ storage site, which is responsible for Ca2+ channel opening. The location of the Ca2+ release site was correlated with a region near the nucleus, probably a specialized region of endoplasmic reticulum. It is proposed that similar mechanisms of Ca2+ signaling occur in mature myeloid cells, such as neutrophils, but on a shorter time scale as a consequence of their smaller size.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Calcium/metabolism*, Calcium Channels/physiology, Cells, Cultured, Cytosol/metabolism, Diffusion, Humans
Publisher: Bethesda, MD : Society for Leukocyte Biology
ISSN: 0741-5400
Last Modified: 28 Oct 2022 09:51

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