Modelling the human respiratory system: Approaches for in vitro safety testing and drug discovery

Prytherch, Zoe Cariad ORCID: https://orcid.org/0000-0003-0690-0184 and Berube, Kelly ORCID: https://orcid.org/0000-0002-7471-7229 2014. Modelling the human respiratory system: Approaches for in vitro safety testing and drug discovery. Human-based Systems for Translational Research, Royal Society of Chemistry, pp. 66-87. (10.1039/9781782620136-00066)

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Abstract

Respiratory research can be broken down into two main areas: (i) exposure to airborne substances (basic toxicology assessment); and (ii) respiratory diseases (understanding disease mechanisms and development of new therapeutics, including toxicological assessment). Both have suffered from inadequate and inaccurate models used to predict human toxicological end points. A growing need therefore exists for accurate in vitro models of the respiratory system, which accurately reflect the human lung situation in vivo. Advances in cell culture techniques and accessibility of human cells/tissues have resulted in the development of increasingly in vivo-like respiratory models. This chapter will focus on the development, advantages and disadvantages of these models and what the future holds for in vitro lung toxicology.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Publisher:	Royal Society of Chemistry
ISBN:	978-1-84973-825-5
Last Modified:	16 Nov 2022 07:49
URI:	https://orca.cardiff.ac.uk/id/eprint/76320

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