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Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception

Hodgetts, Carl J. ORCID:, Postans, Mark, Shine, Jonathan P., Jones, Derek K. ORCID:, Lawrence, Andrew D. ORCID: and Graham, Kim S. ORCID: 2015. Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception. eLife 4 , e07902. 10.7554/eLife.07902

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We tested a novel hypothesis, generated from representational accounts of medial temporal lobe (MTL) function, that the major white matter tracts converging on perirhinal cortex (PrC) and hippocampus (HC) would be differentially involved in face and scene perception, respectively. Diffusion tensor imaging was applied in healthy participants alongside an odd-one-out paradigm sensitive to PrC and HC lesions in animals and humans. Microstructure of inferior longitudinal fasciculus (ILF, connecting occipital and ventro-anterior temporal lobe, including PrC) and fornix (the main HC input/output pathway) correlated with accuracy on odd-one-out judgements involving faces and scenes, respectively. Similarly, BOLD response in PrC and HC, elicited during oddity judgements, was correlated with face and scene oddity performance, respectively. We also observed associations between ILF and fornix microstructure and category-selective BOLD response in PrC and HC, respectively. These striking three-way associations highlight functionally dissociable, structurally instantiated MTL neurocognitive networks for complex face and scene perception.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Cardiff University Brain Research Imaging Centre (CUBRIC)
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: This article is distributed under the terms of the Creative Commons Attribution License.
Publisher: eLife Sciences Publications
ISSN: 2050-084X
Funders: Medical Research Council
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 28 August 2015
Last Modified: 05 Jan 2024 02:40

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