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Profiling depression in childhood and adolescence: the role of conduct problems

Riglin, Lucy, Thapar, Anita ORCID:, Shelton, Katherine H. ORCID:, Langley, Kate ORCID:, Frederickson, Norah and Rice, Frances ORCID: 2016. Profiling depression in childhood and adolescence: the role of conduct problems. Journal of Child Psychology and Psychiatry 57 (4) , pp. 481-490. 10.1111/jcpp.12465

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Background Depression is typically more common in females and rates rise around puberty. However, studies of children and adolescents suggest that depression accompanied by conduct problems may represent a different subtype not characterised by a female preponderance, with differing risk factors and genetic architecture compared to pure-depression. This study aimed to identify aetiologically distinct profiles of depressive symptoms, distinguished by the presence or absence of co-occurring conduct problems. Methods Latent profile analysis was conducted on a school sample of 1648 children (11–12 years) and replicated in a sample of 2006 twins (8–17 years). Results In both samples pure-depressive and conduct-depressive profiles were identified. The pure-depressive profile was associated with female gender, while the conduct-depressive profile was associated with lower cognitive ability but not with gender. Twin analyses indicated possible differences in genetic aetiology. Conclusions There was evidence for aetiologically heterogeneous depression symptom profiles based on the presence or absence of co-occurring conduct problems.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Depression; aetiology; heterogeneity; conduct problems; genetic
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License.
Publisher: Wiley
ISSN: 0021-9630
Funders: Nuffield Foundation, Medical Research Council
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 10 August 2015
Last Modified: 12 Oct 2023 05:33

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