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Epilepsy and deprivation, a data linkage study

Pickrell, William O., Lacey, Arron S., Bodger, Owen G., Demmler, Joanne C., Thomas, Rhys Huw ORCID:, Lyons, Ronan A., Smith, Philip E. M. ORCID:, Rees, Mark I. and Kerr, Michael Patrick 2015. Epilepsy and deprivation, a data linkage study. Epilepsia 56 (4) , pp. 585-591. 10.1111/epi.12942

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Objective To investigate whether the link between epilepsy and deprivation is due to factors associated with deprivation (social causation) or factors associated with a diagnosis of epilepsy (social drift). Methods We reviewed electronic primary health care records from 2004 to 2010, identifying prevalent and incident cases of epilepsy and recording linked deprivation scores. Logistic and Poisson regression models were used to calculate odds ratios and incidence rate ratios. The change in deprivation was measured 10 years after the initial diagnosis of epilepsy for a cohort of people. Results Between 2004 and 2010, 8.1 million patient-years of records were reviewed. Epilepsy prevalence and incidence were significantly associated with deprivation. Epilepsy prevalence ranged from 1.13% (1.07–1.19%) in the most deprived decile to 0.49% (0.45–0.53%) in the least deprived decile (adjusted odds ratio 0.92, p < 0.001). Epilepsy incidence ranged from 40/100,000 per year in the most deprived decile to 19/100,000 per year in the least deprived decile (adjusted incidence rate ratio 0.94, p < 0.001). There was no statistically significant change in deprivation index decile 10 years after a new diagnosis of epilepsy (mean difference −0.04, p = 0.85). Significance Epilepsy prevalence and incidence are strongly associated with deprivation; the deprivation score remains unchanged 10 years after a diagnosis of epilepsy. These findings suggest that increasing rates of epilepsy in deprived areas are more likely explained by social causation than by social drift. The nature of the association between incident epilepsy and social deprivation needs further exploration.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Epilepsy; Deprivation; Incidence; Prevalence
Publisher: Wiley
ISSN: 0013-9580
Date of Acceptance: 15 January 2015
Last Modified: 16 Nov 2022 23:16

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