Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Cardiovascular function in children who had chronic lung disease of prematurity

Joshi, Suchita, Wilson, Dirk G., Kotecha, Sarah, Pickerd, Nicole, Fraser, Alan and Kotecha, Sailesh ORCID: 2014. Cardiovascular function in children who had chronic lung disease of prematurity. Archives of Disease in Childhood. Fetal and neonatal edition 99 (5) , F373-F379. 10.1136/archdischild-2013-305185

Full text not available from this repository.


Objectives: Although increased pulmonary arterial pressure is common in infancy in preterm infants who develop chronic lung disease of prematurity (CLD), it is unknown if the increase persists into childhood. We, therefore, assessed if 8–12-year-old children with documented CLD in infancy had evidence of right ventricular dysfunction or pulmonary arterial hypertension at rest or in response to acute hypoxia when compared to preterm and term-born controls. Methods: We studied 90 children: 60 born at ≤32 weeks of gestation (28 with CLD and 32 preterm controls), and 30 term-born controls. All had echocardiography including myocardial velocity imaging, at rest and while breathing 15% oxygen and 12% oxygen for 20 min each. Results: Baseline oxygen saturation, heart rate, blood pressure and echocardiographic markers of left and right ventricular function were similar in all three groups. While breathing 12% oxygen, the oxygen saturation decreased to 81.9% in the CLD group compared to 85.1% (p<0.05) and 84.7% (p<0.01) in the preterm and term controls, respectively. In response to hypoxia, all three groups showed increases in velocity of tricuspid regurgitation, end-diastolic velocity of pulmonary regurgitation, and right ventricular relaxation time; and decreases in pulmonary arterial acceleration time and the ratio of right ventricular acceleration time to ejection time. However, there were no differences between groups. Conclusions: Childhood survivors of CLD have comparable left and right ventricular function at 8–12 years of age to preterm and term-born children, and no evidence of increased pulmonary arterial pressure even after hypoxic exposure.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Publisher: BMJ Publishing Group
ISSN: 1359-2998
Date of Acceptance: 21 May 2014
Last Modified: 28 Oct 2022 10:29

Citation Data

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item