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State, Matthew and Thapar, Anita ORCID: 2015. Genetics. Thapar, Anita ORCID:, Pine, Daniel S., Leckman, James F., Scott, Stephen, Snowling, Margaret J. and Taylor, Eric, eds. Rutter's Child and Adolescent Psychiatry, Wiley-Blackwell, pp. 303-316. (10.1002/9781118381953.ch24)

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For decades, the familial nature of psychiatric syndromes has been appreciated, but only recently have the tools and methods become available to systematically and reliably identify the specific variations in the genetic code that carry risk for disorders ranging from schizophrenia, to bipolar disorder to ADHD and autism. These developments are contributing to a host of new scientific opportunities, from elaborating the neurobiological mechanisms of serious mental illness, to clarifying the interplay of genes and environment in determining risk and resilience. These advances will increasingly call upon clinicians to have a solid foundation in genetics and to keep a pace with recent advances in the field. In this chapter, we review some of the fundamental principles of human genetics, describe the contribution of genetic epidemiology to understanding psychopathology, consider recent technological and methodological advances in efforts both to identify genes contributing to psychiatric disorders and to elucidate the interplay of genes and environment, and address the relevance of recent findings for the practicing clinician.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Genetics; child psychiatry; molecular genetics; DNA
Publisher: Wiley-Blackwell
ISBN: 9781118381960
Last Modified: 28 Oct 2022 10:29

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