Clinical experience of IL-6 blockade in rheumatic diseases: implications on IL-6 biology and disease pathogenesis

Davies, Ruth and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2014. Clinical experience of IL-6 blockade in rheumatic diseases: implications on IL-6 biology and disease pathogenesis. Seminars in Immunology 26 (1) , pp. 97-104. 10.1016/j.smim.2013.12.002

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Abstract

Interleukin 6 (IL-6) plays a significant role in many rheumatological diseases and has been described as both a pro- and anti-inflammatory cytokine. IL-6 blockade has been investigated in various rheumatic diseases and a humanised anti-IL-6 receptor antibody has been licensed for use in rheumatoid arthritis, systemic and polyarticular juvenile idiopathic arthritis. The increasing clinical experience of IL-6 blockade in rheumatic diseases adds to the existing knowledge regarding the physiological and pathological roles of IL-6.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	Elsevier
ISSN:	1044-5323
Last Modified:	31 Oct 2022 08:55
URI:	https://orca.cardiff.ac.uk/id/eprint/79199

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