Dense calcification in a GH-secreting pituitary macroadenoma

Ibrahim, Ramez, Kalhan, Atul, Lammie, Alistair, Kotonya, Christine, Nannapanenni, Ravindra and Rees, Dafydd Rees ORCID: https://orcid.org/0000-0002-1165-9092 2014. Dense calcification in a GH-secreting pituitary macroadenoma. Endocrinology, Diabetes & Metabolism Case Reports , EDM130079. 10.1530/EDM-13-0079

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Abstract

A 30-year-old female presented with a history of secondary amenorrhoea, acromegalic features and progressive visual deterioration. She had elevated serum IGF1 levels and unsuppressed GH levels after an oral glucose tolerance test. Magnetic resonance imaging revealed a heterogeneously enhancing space-occupying lesion with atypical extensive calcification within the sellar and suprasellar areas. Owing to the extent of calcification, the tumour was a surgical challenge. Postoperatively, there was clinical, radiological and biochemical evidence of residual disease, which required treatment with a somatostatin analogue and radiotherapy. Mutational analysis of the aryl hydrocarbon receptor-interacting protein (AIP) gene was negative. This case confirms the relatively rare occurrence of calcification within a pituitary macroadenoma and its associated management problems. The presentation, biochemical, radiological and pathological findings are discussed in the context of the relevant literature.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	BioScientifica
ISSN:	2052-0573
Date of First Compliant Deposit:	16 September 2019
Date of Acceptance:	23 January 2014
Last Modified:	11 Oct 2023 18:35
URI:	https://orca.cardiff.ac.uk/id/eprint/79219

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