Bertrand, Benoit, Stefan, Loic, Pirrotta, Marc, Monchaud, David, Bodio, Ewen, Richard, Philippe, Le Gendre, Pierre, Warmerdam, Elena, de Jager, Marina H., Groothuis, Geny M. M., Picquet, Michel and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2014. Caffeine-based gold(I) N-heterocyclic carbenes as possible anticancer agents: synthesis and biological properties. Inorganic Chemistry 53 (4) , pp. 2296-2303. 10.1021/ic403011h |
Official URL: http://dx.doi.org/10.1021/ic403011h
Abstract
Organometallic Au(I) NHC compounds bearing caffeine-type ligands have been synthesized and characterized as promising anticancer agents. The bis-carbene complex [Au(caffeine-2-yliene)2][BF4] appeared to be selective for human ovarian cancer cell lines in vitro and poorly toxic in healthy organs ex vivo. The compound shows high affinity and selectivity for G-quadruplex structures as demonstrated by FRET melting assay.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
Publisher: | American Chemical Society |
Last Modified: | 31 Oct 2022 08:57 |
URI: | https://orca.cardiff.ac.uk/id/eprint/79306 |
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