Seven newly identified loci for autoimmune thyroid disease

Cooper, J. D., Simmonds, M. J., Walker, N. M., Burren, O., Brand, O. J., Guo, H., Wallace, C., Stevens, H., Coleman, G., Franklyn, J. A., Todd, J. A., Gough, S. C. L., Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610, Dunajewski, K., Forty, Elizabeth, Green, E., Grozeva, D., Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909 2012. Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics 21 (23) , pp. 5202-5208. 10.1093/hmg/dds357

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Abstract

Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Additional Information:	Nick Craddock, Katherine Dunajewski, Elizabeth Forty, Elaine Green, Detelina Grozeva, Ian Jones, George Kirov, Michael O'Donovan, Michael Owen and Neil Robertson are collaborators on this article.
Publisher:	Oxford University Press
ISSN:	0964-6906
Last Modified:	31 Oct 2022 08:59
URI:	https://orca.cardiff.ac.uk/id/eprint/79405

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