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Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review [Review]

Morgan, James Edwards ORCID: 2012. Retina ganglion cell degeneration in glaucoma: an opportunity missed? A review [Review]. Clinical and Experimental Ophthalmology 40 (4) , pp. 364-368. 10.1111/j.1442-9071.2012.02789.x

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Retinal ganglion cell degeneration has been reported in a range of experimental models of glaucoma. Manifest as pruning of retinal ganglion cell dendrites, it is likely to influence both the function and viability of affected cells. Electrophysiological studies in primate glaucoma have shown that affected cells retain some function and could therefore form a neural substrate for the recovery of visual function in glaucoma. Clinical studies in which the intraocular pressure is reduced have suggested that some improvement in retinal function may be possible in hypotensive eyes. These experimental studies highlight the importance of establishing the extent to which retinal ganglion cell degeneration occurs in human glaucoma. If substantial numbers of degenerating retinal ganglion cells are present in glaucoma, they could present an ideal target for the recovery of vision.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 1442-6404
Last Modified: 31 Oct 2022 09:07

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