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DNA pooling and dense marker maps: a systematic search for genes for cognitive ability

Hill, L., Craig, I. W., Asherson, P., Ball, D., Eley, T., Ninomiya, T., Fisher, P. J., Turic, D., McGuffin, P., Owen, Michael John ORCID:, Chorney, K., Chorney, M. J., Benbow, C. P., Lubinski, D., Thompson, L. A. and Plomin, R. 1999. DNA pooling and dense marker maps: a systematic search for genes for cognitive ability. NeuroReport 10 (4) , pp. 843-848. 10.1097/00001756-199903170-00032

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Pooling DNA from subjects within a group and comparing the pooled DNA across groups for a dense map of DNA markers offers a solution to the conundrum that linkage is systematic but not powerful whereas allelic association is powerful but not systematic. We used DNA pooling to screen 66 markers on chromosome 22 in original and replication samples of children of high general cognitive ability (g) and controls of average g. Although none of these markers survived our three-stage screening design (original pooling, replication pooling, individual genotyping), the results of DNA pooling were largely confirmed by individual genotyping. We can therefore exclude associations of major effect size on chromosome 22 for g, a key variable for cognitive neuroscience research on learning and memory.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Lippincott, Williams & Wilkins
ISSN: 0959-4965
Last Modified: 31 Oct 2022 09:32

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