Intense pulsed light enhances transforming growth factor beta1/Smad3 signaling in acne-prone skin

Ali, M., Porter, Rebecca and Gonzalez, Maria 2013. Intense pulsed light enhances transforming growth factor beta1/Smad3 signaling in acne-prone skin. Journal of Cosmetic Dermatology 12 (3) , pp. 195-203. 10.1111/jocd.12045

Full text not available from this repository.

Abstract

Background: Recently, much interest has been generated in the use of intense pulsed light (IPL) sources in the treatment of various skin conditions. However, the underlying mechanism for its therapeutic action has not been elucidated. Objective: To investigate the effect of IPL on the in vivo expression of transforming growth factor beta1 (TGF-β1) and on the immunolocalization of Smad3 in biopsies obtained from perilesional skin in patients with mild-to-moderate inflammatory acne vulgaris. Methods: Biopsies obtained from 20 patients with inflammatory acne vulgaris at baseline (B1) and post-IPL treatment (B2 = 48 h after first treatment and B3 = 1 week after final treatment) were immunohistochemically analyzed to determine the expression of TGF-β1 and the immunolocalization of Smad3. Digital images were semiquantitatively assessed using image analysis software. Results: Intense pulsed light elicited a consistent increase in epidermal TGF-β1 expression (B2 vs. B1: P = 0.004 and B3 vs. B1: P = 0.007). Furthermore, it resulted in enhanced nuclear immunolocalization of Smad3 (B2 vs. B1: epidermis, P = 0.000055 and dermis, P = 0.014; B3 vs. B1: epidermis, P = 0.00024 and dermis, P = 0.008). Conclusion: Intense pulsed light upregulates TGF-β1/Smad3 signaling in perilesional skin obtained from patients with mild-to-moderate inflammatory acne vulgaris. Further experiments on lesional skin and downstream effects are warranted to determine whether it may play a role in IPL-induced resolution of acne vulgaris.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Acne Vulgaris; Cell Nucleus; Dermis; Disease Susceptibility; Epidermis; Humans; Intense Pulsed Light Therapy; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta1
Publisher:	Wiley
ISSN:	1473-2130
Last Modified:	04 Jun 2017 08:37
URI:	https://orca.cardiff.ac.uk/id/eprint/81446

Citation Data

Cited 13 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item