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A transmission/disequilibrium study of the DRB1*04 gene locus on chromosome 6p21.3 with schizophrenia

Wright, P., Dawson, E., Donaldson, P. T., Underhill, J. A., Sham, P. C., Zhao, J., Gill, M., Nanko, S., Owen, Michael John ORCID:, McGuffin, P. and Murray, R. M. 1998. A transmission/disequilibrium study of the DRB1*04 gene locus on chromosome 6p21.3 with schizophrenia. Schizophrenia Research 32 (2) , pp. 75-80. 10.1016/S0920-9964(98)00050-4

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Previously, a combined analysis by the Chromosome 22 Collaborative Linkage Group (1996; Am. J. Med Genet. 67, 40-45) used an affected sib-pair analysis of a single marker (D22S278) in 574 families multiply affected by schizophrenia and found some evidence for linkage (chi 2 = 9.35, 1 df, p = 0.001), suggesting the presence of a disease locus nearby on chromosome 22q12. In order to further investigate the importance of this result, we have performed the transmission disequilibrium test (TDT) and additional parametric and non-parametric linkage analysis of the same data. The most positive result obtained was an admixture lod score of 0.9 under the assumption of locus heterogeneity and dominant transmission. The result of the TDT analysis was significant at p = 0.015 (allele-wise; chi 2 = 22, 10 df) and p = 0.00016 (genotype-wise; chi 2 = 66.2, 30 df, empirical p value = 0.0009). Overall, these results further strengthen the notion that there is a susceptibility locus for schizophrenia close to D22S278.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier
ISSN: 0920-9964
Last Modified: 31 Oct 2022 09:35

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