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Thyroid disorders in lithium-treated patients

Kirov, George ORCID: 1998. Thyroid disorders in lithium-treated patients. Journal of affective disorders 50 (1) , pp. 33-40.

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BACKGROUND: Little is known about the rate of thyroid disorders prior to lithium treatment, and which patients have a higher risk for developing such disorders during such treatment. METHOD: Assessment of the thyroid histories and laboratory results of 209 lithium-treated patients with affective disorders from one catchment area. RESULTS: Six female patients had thyrotoxicosis before starting lithium, a rate of 4.9%. Twenty patients developed hypothyroidism during the treatment: 3.4% of all males and 14.9% of all females. Female patients over the age of 50 were more likely to develop early lithium-induced hypothyroidism. CONCLUSIONS: (1) Female patients with affective disorders might have an increased rate of thyrotoxicosis. (2) Lithium-induced hypothyroidism might develop earlier in female patients over the age of 50. LIMITATIONS: Retrospective design of the study. CLINICAL RELEVANCE: (1) The thyroid status of patients with affective disorders might be more relevant than is appreciated. (2) Guidelines for thyroid tests in lithium-treated patients should reflect the different risks conferred by age and gender.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier
ISSN: 0165-0327
Last Modified: 31 Oct 2022 09:35

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