Thyroid disorders in lithium-treated patients

Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950 1998. Thyroid disorders in lithium-treated patients. Journal of affective disorders 50 (1) , pp. 33-40.

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Abstract

BACKGROUND: Little is known about the rate of thyroid disorders prior to lithium treatment, and which patients have a higher risk for developing such disorders during such treatment. METHOD: Assessment of the thyroid histories and laboratory results of 209 lithium-treated patients with affective disorders from one catchment area. RESULTS: Six female patients had thyrotoxicosis before starting lithium, a rate of 4.9%. Twenty patients developed hypothyroidism during the treatment: 3.4% of all males and 14.9% of all females. Female patients over the age of 50 were more likely to develop early lithium-induced hypothyroidism. CONCLUSIONS: (1) Female patients with affective disorders might have an increased rate of thyrotoxicosis. (2) Lithium-induced hypothyroidism might develop earlier in female patients over the age of 50. LIMITATIONS: Retrospective design of the study. CLINICAL RELEVANCE: (1) The thyroid status of patients with affective disorders might be more relevant than is appreciated. (2) Guidelines for thyroid tests in lithium-treated patients should reflect the different risks conferred by age and gender.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	0165-0327
Last Modified:	31 Oct 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/81654

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