Dysbindin-1 and schizophrenia: from genetics to neuropathology

Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 2004. Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation 113 (9) , pp. 1255-1257. 10.1172/JCI200421470

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Abstract

The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	American Society for Clinical Investigation
ISSN:	0021-9738
Last Modified:	17 Jul 2023 06:46
URI:	https://orca.cardiff.ac.uk/id/eprint/81686

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