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Polydactyly and psychosis. Five cases of co-occurrence

Cardno, A. G., Murphy, K. C., Jones, L. A., Cobb, A. M., Gray, J., McGuffin, P. and Owen, Michael John ORCID: 1998. Polydactyly and psychosis. Five cases of co-occurrence. British Journal of Psychiatry 172 , pp. 184-185. 10.1192/bjp.172.2.184

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BACKGROUND: Abnormalities presumed to occur during foetal life have been associated with schizophrenia. Polydactyly is a developmental abnormality but no previous association has been reported between polydactyly and functional psychotic illness. METHOD: Individuals with both polydactyly and a functional psychosis were ascertained during a study of familial schizophrenia. RESULTS: Five such individuals were ascertained in the course of assessing 234 individuals with familial psychosis, giving a rate of polydactyly in the sample of around 10 times the general population rate. CONCLUSIONS: This study provides preliminary evidence that polydactyly is over-represented in individuals with familial schizophrenia and related psychotic illnesses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Royal College of Psychiatrists
ISSN: 0007-1250
Last Modified: 31 Oct 2022 09:37

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