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Genomic microarrays in the spotlight

Mantripragada, Kiran Kumar ORCID:, Buckley, Patrick G, Diaz de Ståhl, Teresita and Dumanski, Jan P 2004. Genomic microarrays in the spotlight. Trends in Genetics 20 (2) , pp. 87-94. 10.1016/j.tig.2003.12.008

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Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations. In this article we outline the use and limitations of genomic clones, cDNA clones and PCR products as targets for genomic microarray construction. Furthermore, the applications and future aspects of these arrays for DNA copy number analysis in research and diagnostics, epigenetic profiling and gene annotation are discussed. These recent developments of genomic microarrays mark only the beginning of a new generation of high-resolution and high-throughput tools for genetic analysis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0168-9525
Last Modified: 31 Oct 2022 09:37

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