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Restricted growth potential of rat neural precursors as compared to mouse

Svendsen, C. N., Skepper, J., Rosser, Anne Elizabeth ORCID:, ter Borg, M. G., Tyres, P. and Ryken, T. 1997. Restricted growth potential of rat neural precursors as compared to mouse. Brain research. Developmental brain research 99 (2) , pp. 253-258. 10.1016/S0165-3806(97)00002-3

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Epidermal growth factor (EGF) responsive precursors isolated from the developing mouse striatum could be continually expanded in culture as free-floating spheres of cells for over 50 days. Under identical conditions, EGF-responsive precursors from the developing rat striatum could only be expanded for between 21 and 28 days, after which crisis ensued and there was a reduction in cell number at each passage. The outer regions of 28-day-old rat spheres contained a heterogeneous population of both dividing and dying cells while the cores were full of dying cells, many of which showed features consistent with apoptosis. Fibroblast growth factor-2 (FGF-2) alone did not lead to an expansion in rat striatal precursor cell number under the conditions used here. EGF combined with FGF-2 acted synergistically on cell growth, but did not prevent the final senescence and death of the rat precursors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Elsevier Science Publishers
ISSN: 0165-3806
Last Modified: 31 Oct 2022 09:39

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