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Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells

Rosser, Anne Elizabeth ORCID:, Tyers, P., ter Borg, M., Dunnett, S. B. and Svendsen, C. N. 1997. Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells. Brain research. Developmental brain research 98 (2) , pp. 291-295. 10.1016/S0165-3806(96)00189-7

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In this study we have performed a detailed analysis of EGF-responsive precursors as they develop into neurons and astrocytes using antibodies to nestin, microtubule-associated protein 2 (MAP-2c and MAP-2ab) and glial fibriallary acidic protein (GFAP). Surprisingly, at early time points, most GFAP-positive cells also stained for MAP-2c, and we postulate that this may be a normal stage of astroglial development. At 7 days most of the cells had developed into astrocytes and MAP-2ab-positive cells only represented 5% of the total neuronal population. This study shows that (i) MAP-2c is a marker for early precursors, (ii) the majority of cells developing from. EGF-responsive precursors develop into glia and (iii) only a small population of cells arising from expanded populations of EGF-responsive precursors develop into neurons expressing MAP-2ab. Thus, certain critical signals important for full neuronal differentiation may be missing from this system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier Science Publishers
ISSN: 0165-3806
Last Modified: 31 Oct 2022 09:39

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